产品货号：
Z11919
中文名称：
BMI1抗体
英文名称：
Anti-BMI1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BMI1 Antibody |
| 指标别名 | BMI1;PCGF4;Polycomb complex protein BMI 1;RING finger protein 51;RNF51 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | BMI1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human Bmi1(135-165aa IEFFDQNRLDRKVNKDKEKSKEEVNDKRYLR),different from the related mouse sequence by four amino acids. |
| 实际分子量 | 40KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | BMI1(BMI1 polycomb ring finger oncogene),also known as RNF51,is a protein which in humans is encoded by the BMI1 gene.The Bmi1 gene is highly conserved in evolution as indicated by zoo blot hybridization with Bmi1 probes corresponding to the protein-encoding domain.By fluorescence in situ hybridization,the human BMI1 gene is assigned to chromosome 10p13.BMI1 has a key role in regulating the proliferative activity of normal stem and progenitor cells.Most importantly,they provided evidence that the proliferative potential of leukemic stem and progenitor cells lacking BMI1 is compromised because they eventually undergo proliferation arrest and show signs of differentiation and apoptosis,leading to transplant failure of the leukemia.Complementation studies showed that BMI1 completely rescues these proliferative defects.Deletion analysis showed that the RING finger and helix-turn-helix domains of BMI1 were required for life span extension and repression of the tumor suppressor p16(INK4).BMI1 selectively extended the life span of these cultures.Confocal microscopy showed that BMI1 transiently colocalized with centromeres during interphase in HeLa cells. |
| Uniprot ID | P35226 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | BMI1 proto-oncogene,polycomb ring finger |
| 蛋白名全称 | Polycomb complex protein BMI-1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：BMI1抗体，BMI1多抗，Anti-BMI1 Antibody